Sodium hyaluronate.
At the core of what
we do since 1982.

Offering a variety of molecular weights and custom
modifications for research and clinical applications
that demand the highest quality.

Whether you need research-grade, pharmaceutical and injectable-grade, hydrogels, or custom modifications, we offer a broad range of average molecular weights which can be tailored for use in R&D, clinical, and commercial applications.

All Lifecore products are backed by our extensive quality history, technical support, and responsive service.

Orders and Technical Service

For standard orders and custom modifications, please contact us:

+1 (952) 368-4300 | 1-800-348-4368 (phone menu option 4)

Email us at or send us a web inquiry

High Quality Options

All NaHy is manufactured in powdered form, from pharmaceutical-grade lots or derived from pharmaceutical lots, with an average molecular weight from 5KDa-1.8MDa.

View pricing guide

Hydrogels for Drug Delivery

Corgel® BioHydrogel* products are biocompatible and can be tailored for use across various medical applications.

View pricing guide Learn more

Custom Modifications

Let us help with your custom NaHy tag or chemical modification to get you to a GMP scale and your first-in-human clinical trial.

Learn more

Therapeutic Applications

Our sodium hyaluronate has been used as excipients, carriers and APIs across a wide range of applications, including:

  • Drug delivery
  • Biomaterials
  • Ophthalmology
  • Orthopedics
  • Aesthetics
  • Oncology
  • Pain management

Corgel® BioHydrogel

Lifecore licensed the patented Corgel® BioHydrogel technology from the Cleveland Clinic. Based on di-hydroxyphenyl linkages of tyramine substituted sodium hyaluronate (NaHy), this biocompatible hyaluronan hydrogel meets ISO 10993 safety and toxicity standards.

Corgel® BioHydrogel has a wide range of physical properties depending on the tyramine substitution (TS) percentage and the tyramine substituted hyaluronan (TS-NaHy) concentration. Our hydrogels are formed from TS-NaHy solutions of 6.25 – 100 mg/mL and display a spectrum of physical properties that include those of a weak gel, a paste, or a fragile solid.

  • Corgel® Kits are available with 1%, 3%, or 5% TS of NaHy.
  • Depending on the targeted TS-NaHy concentration, Corgel® Kits yield a total of between 5 and 50mLs.


Do you need a tunable hydrogel?

Corgel® BioHydrogel can be formed under physiologic conditions, allowing for the direct inclusion of cells or bioactive agents prior to or during cross-linking. Alternatively, in situ cross-linking directly adjacent to living tissue can be done while maintaining cell and tissue viability.

The degree of substitution required for using Corgel® is very low (1% – 5%), meaning that much of the native sodium hyaluronate structure and behavior can be maintained.

Both the functional groups and the resulting cross-linked structures have unique photometric properties that allow for the evaluation of the degree of substitution and cross-linking.

View pricing guide Orders and Technical Service View cross-linking procedure

Custom Modifications

We help you tailor and enhance the function of NaHy:

  • Cross-linking
  • Add pendant groups, APIs or custom linkers
  • Pilot production and scale-up to a cGMP process
  • Other modifications

We collaborate with you to develop manufacturing processes and scale your product from formulation and pilot studies all the way to cGMP manufacturing (clinical and commercial).

Contact us to discuss custom NaHy

Beyond our NaHy legacy, our expertise empowers drug development, innovation, and manufacturing for others.

Discover Development Options

Decades working with highly viscous products (>100,000 cP) mean we know how to do straightforward-to-difficult development the right way, from the start.

Maximize Your Manufacturing

As a full-service CDMO, we help simplify complexities for all clinical and commercial aseptic injectable products.

*Corgel® BioHydrogel technology is covered by US patents 6,982,298; 7,368,502; 7,465,766. Cleveland Clinic is a © of The Cleveland Clinic Foundation. Lifecore Biomedical and Corgel are trademarks of Lifecore Biomedical.

Large-Scale, Reproducible Process

U.S.-manufactured for more than 40 years using a microbial fermentation and purification process which sets the industry standard.

Global Approvals

  • U.S. DMF (FDA for drug and device)
  • EP-certified
  • JP-compliant

Proven Applications Worldwide

  • Currently manufacture 20+ commercially approved injectable products containing sodium hyaluronate
  • Used in the treatment of more than 100 million patients