Whether you need research-grade, pharmaceutical and injectable-grade, hydrogels, or custom modifications, we offer a broad range of average molecular weights which can be tailored for use in R&D, clinical, and commercial applications.
All Lifecore products are backed by our extensive quality history, technical support, and responsive service.
Orders and Technical Service
For standard orders and custom modifications, please contact us:
+1 (952) 368-4300 | 1-800-348-4368 (phone menu option 4)
Email us at info@lifecore.com or send us a web inquiry
High Quality Options
All NaHy is manufactured in powdered form, from pharmaceutical-grade lots or derived from pharmaceutical lots, with an average molecular weight from 5KDa-1.8MDa.
Hydrogels for Drug Delivery
Corgel® BioHydrogel* products are biocompatible and can be tailored for use across various medical applications.
Custom Modifications
Let us help with your custom NaHy tag or chemical modification to get you to a GMP scale and your first-in-human clinical trial.
Therapeutic Applications
Our sodium hyaluronate has been used as excipients, carriers and APIs across a wide range of applications, including:
- Drug delivery
- Biomaterials
- Ophthalmology
- Orthopedics
- Aesthetics
- Oncology
- Pain management
Corgel® BioHydrogel
Lifecore licensed the patented Corgel® BioHydrogel technology from the Cleveland Clinic. Based on di-hydroxyphenyl linkages of tyramine substituted sodium hyaluronate (NaHy), this biocompatible hyaluronan hydrogel meets ISO 10993 safety and toxicity standards.
Corgel® BioHydrogel has a wide range of physical properties depending on the tyramine substitution (TS) percentage and the tyramine substituted hyaluronan (TS-NaHy) concentration. Our hydrogels are formed from TS-NaHy solutions of 6.25 – 100 mg/mL and display a spectrum of physical properties that include those of a weak gel, a paste, or a fragile solid.
- Corgel® Kits are available with 1%, 3%, or 5% TS of NaHy.
- Depending on the targeted TS-NaHy concentration, Corgel® Kits yield a total of between 5 and 50mLs.
Do you need a tunable hydrogel?
Corgel® BioHydrogel can be formed under physiologic conditions, allowing for the direct inclusion of cells or bioactive agents prior to or during cross-linking. Alternatively, in situ cross-linking directly adjacent to living tissue can be done while maintaining cell and tissue viability.
The degree of substitution required for using Corgel® is very low (1% – 5%), meaning that much of the native sodium hyaluronate structure and behavior can be maintained.
Both the functional groups and the resulting cross-linked structures have unique photometric properties that allow for the evaluation of the degree of substitution and cross-linking.
Custom Modifications
We help you tailor and enhance the function of NaHy:
- Cross-linking
- Add pendant groups, APIs or custom linkers
- Pilot production and scale-up to a cGMP process
- Other modifications
We collaborate with you to develop manufacturing processes and scale your product from formulation and pilot studies all the way to cGMP manufacturing (clinical and commercial).
Beyond our NaHy legacy, our expertise empowers drug development, innovation, and manufacturing for others.
Discover Development Options
Decades working with highly viscous products (>100,000 cP) mean we know how to do straightforward-to-difficult development the right way, from the start.
Maximize Your Manufacturing
As a full-service CDMO, we help simplify complexities for all clinical and commercial aseptic injectable products.
*Corgel® BioHydrogel technology is covered by US patents 6,982,298; 7,368,502; 7,465,766. Cleveland Clinic is a © of The Cleveland Clinic Foundation. Lifecore Biomedical and Corgel are trademarks of Lifecore Biomedical.

Large-Scale, Reproducible Process
U.S.-manufactured for more than 40 years using a microbial fermentation and purification process which sets the industry standard.
Global Approvals
- U.S. DMF (FDA for drug and device)
- EP-certified
- JP-compliant
Proven Applications Worldwide
- Currently manufacture 20+ commercially approved injectable products containing sodium hyaluronate
- Used in the treatment of more than 100 million patients