Corgel® BioHydrogel

Corgel® BioHydrogel is a biocompatible, patented hyaluronan hydrogel based on di-hydroxyphenyl linkages of tyramine substituted sodium hyaluronate (NaHy). Lifecore has licensed this technology from the Cleveland Clinic and has completed ISO 10993 safety and toxicity studies on this patented technology.

The resulting Corgel® has a wide range of physical properties depending on the tyramine substitution (TS) percentage and the tyramine substituted hyaluronan (TS-NaHy) concentration. Hydrogels formed from TS-NaHy solutions of 6.25 - 100 mg/mL display a spectrum of physical properties that include those of a weak gel, a paste, or a fractile solid.

  • Corgel® Kits are available with 1%, 3%, or 5% TS of the NaHy.
  • Depending on the targeted TS-NaHy concentration, Corgel® Kits yield a total of between 5 and 50mLs.

Corgel® Advantages

  • In situ crosslinking
  • Maintains biocompatibility
  • Tunable physical properties
  • Controlled bioresorption
  • Provides easy characterization, quality control, and in vivo detection
  • Integrates with existing tissue matrices
  • Direct inclusion of cells and bioactive factors
  • Maintains cell and tissue viability

 

 

 

 

 

Potential Corgel® Applications

  • Adhesion Prevention
  • Aesthetics
  • Cardiology
  • Cell/Stem Cell/Biomarker Delivery
  • Drug Delivery
  • ENT
  • Ophthalmology
  • Orthopedics
  • Regenerative Medicine
  • Tissue Engineering
  • Tissue/Organ Preservation
  • Urology
  • Vascular Surgery
  • Wound Care

CORGEL INSTRUCTIONS

Corgel®Kits are available with 1%, 3%, or 5% tyramine substitution.

Depending on the targeted TS-NaHy concentration, Corgel®Kits yield a total of between 5 and 50mLs. Please see the Instructions for proper use.

DETAILED EXPLANATION OF THE CHEMISTRY OF CORGEL

Corgel® is for RESEARCH USE ONLY, NOT FOR HUMAN USE.

Both the functional groups, and the resulting cross-linked structures, have unique photometric properties that allow for easy evaluation of the degree of substitution and cross-linking. Importantly, the degree of substitution required for using Corgel is very low (1% - 5%), maintaining the native sodium hyalruonate structure.

A benefit of the Corgel technology is that this proprietary hydrogel can be formed under physiologic conditions. This allows for the direct inclusion of cells or bioactive agents prior to, during cross-linking, or alternatively, cross-linking directly adjacent to living tissue, maintaining cell and tissue viability.

Attached is a video showing Corgel's ability to occlude flow.  This is just one potential example of Corgel's possible uses in transcatheter applications.  The gel in the video was colored for viewing purposes only.

Publications Referencing Corgel®

General Information on the FDA's Position on Cell/Scaffold Products

General Information Discussing Hyaluronan-Based Hydrogels

Corgel® BioHydrogel Pricing

One Corgel® Kit includes 250 mg of Tyramine-Substituted Sodium Hyaluronate (TS-NaHy), 25 mL Horseradish Peroxidase (HRP) in PBS (10 U/mL), and 5mL Hydrogen Peroxide (H2O2) in PBS (1.0%).

Corgel® Kit Pricing

Part #ENG-00150 Corgel® Kit 1%
$150 per Kit
Part #ENG-00151 Corgel® Kit 3%
$150 per Kit
Part #ENG-00152 Corgel® Kit 5%
$150 per Kit

Corgel® Sampler Pack includes one Kit of each substitution

  • Part #ENG-00150 Corgel® Kit 1%
  • Part #ENG-00151 Corgel® Kit 3%
  • Part #ENG-00152 Corgel® Kit 5%
  • Total: $400 (an 11% savings)

Corgel® Powder includes 250 mg powder, Tyramine-Substituted Sodium Hyaluronate (TS-NaHy)

Product Name
Bottles
Part #85 Corgel® Powder 1%
$125 per Bottle
Part #85 Corgel® Powder 3%
$125 per Bottle
Part #85 Corgel® Powder 5%
$125 per Bottle

 

 

Plus $25 per order for special handling.

RESEARCH USE ONLY, NOT FOR HUMAN USE.

To place an order, please email: rebecca.sebasky@lifecore.com or phone: 952-368-6321 or 800-348-4368, ext. 6321.

Corgel®BioHydrogel (TS-NaHy) technology is covered by US patents 6,982,298; 7,368,502; 7,465,766
Cleveland Clinic is a © of The Cleveland Clinic Foundation
Lifecore Biomedical and Corgel are trademarks of Lifecore Biomedical, LLC.